In Vitro Toxicokinetics and Dynamics: Modeling and Interpretation of Toxicity Data

Abstract Knowledge about toxicokinetics and toxicodynamics is of crucial importance for various areas of pharmaceutical research. Toxicokinetics is generally regarded as an area of science that deals with kinetics of exposure, absorption, distribution, metabolism, and excretion of test compounds and metabolites. This article describes in vitro concentration‐effect relationships and also discusses tools to elucidate the toxicomechanisms under in vitro conditions.