化学
半胺
三氟甲基
二硅烷
路易斯酸
试剂
氟
催化作用
表面改性
甲酰胺
组合化学
硅烷
有机化学
物理化学
烷基
作者
Shawn E. Wright,Jeffrey S. Bandar
摘要
We report a trifluoromethylarene reductive coupling method that dramatically expands the scope of difluorobenzylic substructures accessible via C–F bond functionalization. Catalytic quantities of a Lewis base, combined with a disilane reagent in formamide solvent, promotes the replacement of a single trifluoromethyl fluorine atom with a silylated hemiaminal functional group. The reaction proceeds through a difluorobenzyl silane intermediate that can also be isolated. Together, these defluorinated products are shown to provide rapid access to over 20 unique difluoroalkylarene scaffolds.
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