微泡
癌症研究
三阴性乳腺癌
体内
转移
医学
下调和上调
小RNA
生物
癌症
乳腺癌
内科学
生物化学
生物技术
基因
作者
Xinli Liu,Ge Zhang,Tongyao Yu,Jinliang He,Jie Liu,Xiaoxia Chai,Gang Zhao,Da‐Chuan Yin,Chenyan Zhang
出处
期刊:Cancer Letters
[Elsevier]
日期:2022-09-01
卷期号:543: 215781-215781
被引量:29
标识
DOI:10.1016/j.canlet.2022.215781
摘要
Triple-negative breast cancer (TNBC) is a rapidly recurring and highly metastatic malignancy with high heterogeneity and chemoradiotherapy resistance. Chronic unpredictable mild stress (CUMS) can induce the occurrence of tumors and enhance lymphatic infiltration and distant metastasis through direct interaction with the sympathetic nervous system; however, its relevance in TNBC is yet to be clarified. In this study, DARS-AS1, a newly reported CUMS-responsive lncRNA, was found to be enriched in TNBC clinical tumors and cells and positively correlated with late clinical stage in patients with TNBC. DARS-AS1 overexpression significantly enhanced the migration and invasion of TNBC tumors by inhibiting miR-129-2-3p and upregulated CDK1 to activate the NF-κB/STAT3 signaling pathway both in vitro and in vivo. Treatment with DARS-AS1 siRNA-loaded exosomes (EXOs) substantially slowed CUMS-induced TNBC cell growth and liver metastasis. Therefore, DARS-AS1 represents a potential therapeutic target for metastatic TNBC, and EXOs may serve as siRNA delivery carriers in clinical therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI