再生(生物学)
生物
轴突
再生医学
神经科学
细胞生物学
解剖
自残
雪旺细胞
干细胞
作者
Adam Johnston,Freda D. Miller
出处
期刊:Cold Spring Harbor Perspectives in Biology
[Cold Spring Harbor Laboratory]
日期:2022-06-06
卷期号:14 (9): a041233-a041233
被引量:1
标识
DOI:10.1101/cshperspect.a041233
摘要
Animals such as amphibians have an incredible capacity for regeneration with some being able to regrow their tail or appendages. Although some mammalian tissues like the skin and bones can repair following injury, there are only a few examples of true multilineage regeneration, including the distal portion of the digit tip. In both amphibians and mammals, however, to achieve successful repair or regeneration, it is now appreciated that intact nerve innervation is a necessity. Here, we review the current state of literature and discuss recent advances that identify axon-derived signals, Schwann cells, and nerve-derived mesenchymal cells as direct and indirect supporters of adult tissue homeostasis and repair. We posit that understanding how nerves positively influence repair and regeneration could lead to targeted regenerative medicine strategies to enhance tissue repair in humans.
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