DU145型
癌症
靶向治疗
癌症研究
光热治疗
甘露糖
纳米技术
材料科学
肺癌
癌细胞
化学
生物化学
生物
医学
肿瘤科
LNCaP公司
内科学
作者
Chang‐Hee Whang,Jungwoo Hong,Do-Hyeon Kim,Hong Ryu,Woong Jung,Youngju Son,Hyeongseop Keum,Jinjoo Kim,Hocheol Shin,Eugene Moon,Ilkoo Noh,Heeseung Lee,Sangyong Jon
标识
DOI:10.1002/adma.202203993
摘要
Cancer-targeting ligands used for nanomedicines have been limited mostly to antibodies, peptides, aptamers, and small molecules thus far. Here, a library of glycocalyx-mimicking nanoparticles as a platform to enable screening and identification of cancer-targeting nanomedicines is reported. Specifically, a library of 31 artificial glycopolymers composed of either homogeneous or heterogeneous display of five different sugar moieties (β-glucose, β-galactose, α-mannose, β-N-acetyl glucosamine, and β-N-acetyl galactosamine) is converted to a library of glyconanoparticles (GlyNPs). GlyNPs optimal for targeting CT26, DU145, A549, and PC3 tumors are systematically screened and identified. The cypate-conjugated GlyNP displaying α-mannose and β-N-acetyl glucosamine show selective targeting and potent photothermal therapeutic efficacy against A549 human lung tumors. The docetaxel-contained GlyNP displaying β-glucose, β-galactose, and α-mannose demonstrate targeted chemotherapy against DU145 human prostate tumors. The results presented herein collectively demonstrate that the GlyNP library is a versatile platform enabling the identification of cancer-targeting glyconanoparticles and suggest its potential applicability for targeting various diseased cells beyond cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI