生物
树突状细胞
启动(农业)
抗原
免疫学
细胞生物学
电池类型
抗原提呈细胞
免疫系统
神经科学
T细胞
细胞
遗传学
植物
发芽
作者
Christophe Macri,Ee Shan Pang,Timothy Patton,Meredith O‘Keeffe
标识
DOI:10.1016/j.semcdb.2017.12.009
摘要
Dendritic cells (DC) are professional antigen presenting cells comprising a variety of subsets, as either resident or migrating cells, in lymphoid and non-lymphoid organs. In the steady state DC continually process and present antigens on MHCI and MHCII, processes that are highly upregulated upon activation. By expressing differential sets of pattern recognition receptors different DC subsets are able to respond to a range of pathogenic and danger stimuli, enabling functional specialisation of the DC. The knowledge of functional specialisation of DC subsets is key to efficient priming of T cells, to the design of effective vaccine adjuvants and to understanding the role of different DC in health and disease. This review outlines mouse and human steady state DC subsets and key attributes that define their distinct functions.
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