Antinuclear antibodies induced by isoniazid. A prospective study.

We prospectively studied antinuclear antibodies induced by isoniazid in 109 patients with pulmonary tuberculosis. Ten of 50 patients (20.0%) with complete follow-up developed antinuclear antibodies after anti-tuberculous treatment. None developed symptoms of systemic lupus erythematosus. Female had a higher incidence to develop antinuclear antibodies than men (p＜0.01). Antinuclear antibodies in these patients were treated with various antituberculosis drugs, isoniazid was the only drug that can induce antinuclear antibodies.