Hormone, lectin and toxin-toxin conjugates

In order to better understand the relative importance of the A and B chains of diphtheria toxin and ricin, chimeras or hybrid toxins have been constructed with diphtheria toxin subunits and ricin subunits coupled to a number of different binding moieties. These experiments have demonstrated wide variations in cytotoxicity depending on the specific combinations of A chain and binding moiety.