The influence of the dental papilla on the development of tooth shape in embryonic mouse tooth germs

ABSTRACT Studies of epithelio-mesenchymal interactions during embryonic organogenesis have led to a number of conclusions regarding (he nature of cellular and tissue differentiation (McLoughlin, 1963; Grobstein, 1967). For example, the importance of both the epithelium and the mesenchyme and the dependence of some systems on a limited number of specific mesenchymal tissues have been pointed out (Hilfer, 1968).