生物
受体
白细胞介素-21受体
分子生物学
普通伽马链
白细胞介素-4受体
细胞因子受体
5-HT5A受体
白细胞介素1受体,I型
重组DNA
分子克隆
白细胞介素-1受体
同源(生物学)
互补DNA
克隆(编程)
生物化学
细胞因子
基因
遗传学
白细胞介素
计算机科学
程序设计语言
作者
Raymond G. Goodwin,Della Friend,Steven F. Ziegler,R Jerzy,Ben Falk,Steven D. Gimpel,David Cosman,Steven K. Dower,Carl J. March,Anthony E. Namen,Linda Park
出处
期刊:Cell
[Elsevier]
日期:1990-03-23
卷期号:60 (6): 941-951
被引量:599
标识
DOI:10.1016/0092-8674(90)90342-c
摘要
cDNA clones encoding the human and murine interleukin-7 (IL-7) receptor were isolated and expressed in COS-7 cells. Binding of radiolabeled IL-7 to the recombinant IL-7 receptors produced curvilinear Scatchard plots containing high and low affinity classes. These binding properties, as well as the molecular size of the cloned receptor, were comparable to the native forms of the IL-7 receptor. In addition, several cDNA clones were isolated that encode a secreted form of the human IL-7 receptor capable of binding IL-7 in solution. Analysis of the sequence of the IL-7 receptor revealed significant homology in the extracellular domain to several recently cloned cytokine receptors, demonstrating that the IL-7 receptor is a member of a new receptor superfamily.
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