Linoleic Acid Hydroperoxide: Impaired Bacterial Uptake by Alveolar Macrophages, a Mechanism of Oxidant Lung Injury

Exogenous linoleic acid hydroperoxide causes in vitro impairment of both bacterial uptake and the phagocytic stimulation of 14 CO 2 production from [1- 14 C]glucose in rabbit alveolar macrophages by an undefined effect on the cell membrane. This effect may be one mechanism for the defective pulmonary bacterial clearance characteristic of oxidant lung injury.