组蛋白脱乙酰基酶5
HDAC11型
组蛋白脱乙酰基酶2
HDAC10型
SAP30型
细胞生物学
组蛋白H4
组蛋白H2A
HDAC4型
组蛋白
染色质
转录调控
生物
组蛋白脱乙酰基酶
转录因子
调节器
抄写(语言学)
分子生物学
基因表达调控
乙酰化
染色质免疫沉淀
化学
染色质重塑
酿酒酵母
表观遗传学
组蛋白密码
基因
生物化学
DNA
作者
Jack Taunton,Christian A. Hassig,Stuart L. Schreiber
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1996-04-19
卷期号:272 (5260): 408-411
被引量:1564
标识
DOI:10.1126/science.272.5260.408
摘要
Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo and causes mammalian cells to arrest in the cell cycle. A trapoxin affinity matrix was used to isolate two nuclear proteins that copurified with histone deacetylase activity. Both proteins were identified by peptide microsequencing, and a complementary DNA encoding the histone deacetylase catalytic subunit (HD1) was cloned from a human Jurkat T cell library. As the predicted protein is very similar to the yeast transcriptional regulator Rpd3p, these results support a role for histone deacetylase as a key regulator of eukaryotic transcription.
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