多态性(计算机科学)
固态
药物开发
生化工程
药品
计算生物学
纳米技术
化学
计算机科学
生物技术
材料科学
生物
遗传学
等位基因
工程类
药理学
基因
物理化学
作者
Alfred Y. Lee,Deniz Erdemir,Allan S. Myerson
标识
DOI:10.1146/annurev-chembioeng-061010-114224
摘要
Polymorphism in molecular crystals is a prevalent phenomenon and is of great interest to the pharmaceutical community. The solid-state form is a key quality attribute of a crystalline product. Inconsistencies in the solid phase produced during the manufacturing and storage of drug substances and drug products may have severe consequences. It is essential to understand the solid-state behavior of the drug and to judiciously select the optimal solid form for development. This review highlights the pervasiveness and relevance of polymorphism and describes solid form screening and selection processes. Moreover, case studies on controlling polymorphs from a chemical development perspective are provided.
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