医学
入射(几何)
恶性肿瘤
移植
肾移植
癌症
皮肤癌
内科学
单中心
膀胱癌
人口
胃肠病学
环境卫生
光学
物理
作者
Qiang Sun,Xue Li,Donghui Cheng,Qunpeng He,Jinsong Chen,Song Ji,Zhihong Liu
出处
期刊:PubMed
日期:2011-01-01
卷期号:12 (12): 3347-51
摘要
Malignancy is one of the main complications after renal transplantation but the situation in Chinese renal allograft recipients remains an enigma. We therefore reviewed 1,000 (8,531 person-years follow-up) renal allograft recipients from Jinling Hospital, Nanjing University, revealing an incidence rate of 2.4% of post-transplant malignancies, with a standardized incidence ratio (SIR) of 17.8 (95% C.I.: 16.7-18.8); the standardized rate is 1.67%, compared with 0.29% in the general population. However, our group demonstrated an extremely low incidence of skin cancer, which dominates in western countries. To confirm the findings, we reviewed the literature on post-transplant malignancies in Chinese renal allograft recipients, covering 296 malignancies in 18,548 renal transplant recipients in 21 reports. The top three most common sites of malignancies were the digestive tract, bladder and liver. The incidence of skin cancer was very low in most centers. These data show that Chinese renal allograft recipients have a unique spectrum of post-transplant malignancies, with an extremely very low incidence of skin cancer as compared to populations from western countries.
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