Neoteric Direct Physical Approaches in TDDS: A Boon for PermeationEnhancement

Abstract: Human skin has been tremendously explored for decades as a potential route for the delivery of various substances. It has shown great applications to deliver drugs to systemic circulation as well as has provided adequate advantages to treat local manifestations over the skin. However, the rigid stratum corneum layer has served as the biggest barrier in transdermal drug delivery; various methods have been designed to overcome the stratum corneum layer and make the molecule pass through this. These methods were then broadly classified into chemical and physical approaches. The below study is an overall review of the physical approaches being used in transdermal drug delivery for overcoming the stratum corneum layer. Physical approaches also include direct and indirect methods; we will be physically considering the direct approaches herein.