下调和上调
转录组
生物
甲基化
计算生物学
基因
基因表达
遗传学
作者
Huan Wang,Ren Biao Chen,Si Ni Zhang,Ruifang Zhang
出处
期刊:BMC Genomics
[Springer Nature]
日期:2022-01-07
卷期号:23 (1)
被引量:15
标识
DOI:10.1186/s12864-021-08188-8
摘要
Long non-coding RNAs (lncRNAs) play a critical role in the pathogenesis of hypoxic pulmonary hypertension (HPH). The role of N7-methylguanosine (m7G) modification in lncRNAs has received increased attentions in recent years. However, the m7G-methylation of lncRNA in HPH has yet to be determined. We have therefore performed a transcriptome-wide analysis of m7G lncRNAs in HPH.Differentially-expressed m7Gs were detected in HPH, and m7G lncRNAs were significantly upregulated compared with non-m7G lncRNAs in HPH. Importantly, this was the first time that the upregulated m7G lncXR_591973 and m7G lncXR_592398 were identified in HPH.This study provides the first m7G transcriptome-wide analysis of HPH. Importantly, two HPH-associated m7G lncRNAs were identified, although their clinical significance requires further validation.
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