对映选择合成
化学
环丁烷
表面改性
环应变
组合化学
劈理(地质)
立体化学
键裂
戒指(化学)
有机化学
催化作用
断裂(地质)
工程类
物理化学
岩土工程
作者
Jun Chen,Qiang Zhou,Hanming Fang,Ping Lu
标识
DOI:10.1002/cjoc.202100879
摘要
Comprehensive Summary Cyclobutane derivatives have been recognized as useful structural motifs in organic synthesis and drug design. With the revival of photochemistry, the enantioselective synthesis of cyclobutane derivatives using [2 + 2]‐cycloadditions has garnered numerous attentions. On the other hand, enantioselective functionalization of preformed four‐membered carbocycles is emerging as an important complementary approach to access chiral cyclobutane derivatives with versatile structural patterns. Herein, we summarize recent advances in this field from 2012. To avoid undesired C—C bond cleavage driven by strain‐releasing, it is crucial to choose compatible methods for enantioselective functionalization and meanwhile preserving intact four‐membered ring skeleton. Guided by calculated hydrogenation enthalpies, which are used to evaluate the strain energy of indicated C—C bond, a clear picture of the developed methodologies on functionalization of four‐membered carbocycles combining the strain energy and enhanced reactivity is presented.
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