POS-240 CGAS/STING DECREATES RENAL FIBROSIS AND INFLAMMATORY RESPONSE INDUCED BY HYPERTENSION BY REGULATING GLUTATHINE METABOLISN

Hypertension, an important risk factor for cardiovascular and end-stage renal disease, often aggravates renal injury and compromises kidney function. Renovascular hypertension (RVH) is one of the most common causes of secondary hypertension. Ischemia hypoxia and activation of Renin-angiotensin-aldosterone System (RAAS) are the main pathologic processes of this disease.Blockade of RAAS by administration of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin-receptor blockers (ARBs) can dramatically remove renal function.