Insight into amyloid interactions and aggregation processes: Molecular dynamics simulations of amyloid fragments and full-length oligomers

Amyloids and the associated aggregation and oligomer-formation process can be influenced and exacerbated by the quantity and type of other amyloid peptides present. Amyloid-beta (Aβ) and islet amyloid polypeptide (IAPP) are amyloidogenic peptides that have the potential to self-assemble and form cytotoxic species that are observed as a range from small soluble oligomers and large