烯醇化酶
生物化学
膦酸盐
化学
立体化学
活动站点
糖酵解
水解酶
酶
生物
免疫学
免疫组织化学
作者
Paul G. Leonard,Nikunj Satani,David S. Maxwell,Yu-Hsi Lin,Naima Hammoudi,Zhenghong Peng,Federica Pisaneschi,Todd Link,Gilbert R. Lee,Duoli Sun,Basvoju A. Bhanu Prasad,Maria Emilia Di Francesco,Barbara Czakó,John M. Asara,Yanru Wang,William G. Bornmann,Ronald A. DePinho,Florian L. Müller
标识
DOI：10.1038/nchembio.2195
摘要
SF2312, a phosphonate antibiotic, directly binds and inhibits the activity of the glycolytic enzyme enolase and is selectively toxic to ENO1-deleted glioma cells through inhibition of glycolysis and depletion of ATP.
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