Finding an Area with Close Phenotype Values to Predict Proteins That Control Phenotypes

Because phenotypes of living creatures are ex- pressed reflecting on interactions among genes and proteins, relations among phenotypes and proteins (or genes) have been regarded as a key issue to be clarified to understand the sys- tem of creatures. In this paper, we try to find the relation among two proteins A, B, and a phenotype P, where there is a group of samples G, whose expression levels of A and B are both close to one another, and they always have close values of P. In this paper, we propose a method to extract a pair of proteins that effect on a target phenotype, from a dataset that consists of protein expression profiles and phenotype values.