ATF6
脂质代谢
细胞生物学
生物
未折叠蛋白反应
转录因子
碳水化合物代谢
XBP1型
化学
内质网
生物化学
基因
RNA剪接
核糖核酸
作者
Jianjing Yang,Xiaojie Wu,Xiaoting Wu,Dijia Zhou,Tengmei Lin,Saidan Ding,Yu Zhang,Jian Xue,Qichuan Zhuge
出处
期刊:Current Protein & Peptide Science
[Bentham Science]
日期:2017-04-17
卷期号:18 (6): 630-635
被引量:18
标识
DOI:10.2174/1389203717666160627085011
摘要
X-box binding protein1 (XBP1) especially exerts its fundamental effects in the cellular organelle endoplasmic reticulum (ER) via affecting three trans-membrane stress sensor proteins: PKRlike ER kinase (PERK), inositol-requiring enzyme 1(IRE1) and activating transcription factor 6(ATF6). At the center of XBP1's broad effects is its remarkable metabolic housekeeper function. XBP1 decreased glucose dysfunction via funneling its effects on improving insulin sensitivity and stimulating insulin secretion. However, XBP1 also yields its double-edged effects, driving the transformation from excess glucose to lipid, which is a key contribution to obesity and T2DM. In this review, we highlight the vital mechanism of XBP1 in manipulating glucose and lipid metabolism involved by multiple signaling pathways.
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