生发中心
间质细胞
免疫系统
间充质干细胞
生物
滤泡树突状细胞
细胞生物学
淋巴结间质细胞
免疫学
B细胞
电池类型
抗原提呈细胞
抗体
T细胞
细胞
癌症研究
遗传学
作者
Alice E. Denton,Michelle A. Linterman
标识
DOI:10.1016/j.coi.2017.03.001
摘要
Secondary lymphoid organs are organized into distinct zones, governed by different types of mesenchymal stromal cells. These stromal cell subsets are critical for the generation of protective humoral immunity because they direct the migration of, and interaction between, multiple immune cell types to form the germinal centre. The germinal centre response generates long-lived antibody-secreting plasma cells and memory B cells which can provide long-term protection against re-infection. Stromal cell subsets mediate this response through control of immune cell trafficking, activation, localization and antigen access within the secondary lymphoid organ. Further, distinct populations of stromal cells underpin the delicate spatial organization of immune cells within the germinal centre. Because of this, the interactions between immune cells and stromal cells in secondary lymphoid organs are fundamental to the germinal centre response. Herein we review how this unique relationship leads to effective germinal centre responses.
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