蛛网膜下腔出血
医学
血管痉挛
脑血管痉挛
经颅多普勒
缺血
脑血流
脑动脉
麻醉
心脏病学
作者
Axel Neulen,Michael Molitor,Michael Kosterhon,Tobias Pantel,Susanne Karbach,Philip Wenzel,Thomas Gaul,Florian Ringel,Serge C. Thal
摘要
Cerebral vasospasm that occurs in the weeks after subarachnoid hemorrhage, a type of hemorrhagic stroke, contributes to delayed cerebral ischemia. A problem encountered in experimental studies using murine models of SAH is that methods for in vivo monitoring of cerebral vasospasm in mice are lacking. Here, we demonstrate the application of high frequency ultrasound to perform transcranial Duplex sonography examinations on mice. Using the method, the internal carotid arteries (ICA) could be identified. The blood flow velocities in the intracranial ICAs were accelerated significantly after induction of SAH, while blood flow velocities in the extracranial ICAs remained low, indicating cerebral vasospasm. In conclusion, the method demonstrated here allows functional, noninvasive in vivo monitoring of cerebral vasospasm in a murine SAH model.
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