Bioinspired mononuclear Mn complexes for O2 activation and biologically relevant reactions

A general interest in harnessing the oxidizing power of dioxygen (O₂) continues to motivate research efforts on bioinspired and biomimetic complexes to better understand how metalloenzymes mediate these reactions. The ubiquity of Fe- and Cu-based enzymes attracts significant attention and has resulted in many noteworthy developments for abiotic systems interested in direct O₂ reduction and small molecule activation. However, despite the existence of Mn-based metalloenzymes with important O₂-dependent activity, there has been comparatively less focus on the development of these analogues relative to Fe- and Cu-systems. In this Perspective, we summarize important contributions to the development of bioinspired mononuclear Mn complexes for O₂ activation and studies on their reactivity, emphasizing important design parameters in the primary and secondary coordination spheres and outlining mechanistic trends.