间充质干细胞
间质细胞
胶原酶
纤维化
软组织
肺
炎症
化学
细胞生物学
病理
细胞外基质
医学
生物
免疫学
内科学
生物化学
酶
作者
Sing Wan Wong,Chandramohan R. Tamatam,Ik Sung Cho,Péter T. Tóth,Raymond Bargi,Patrick Belvitch,James C. Lee,Jalees Rehman,Sekhar P. Reddy,Jae‐Won Shin
标识
DOI:10.1038/s41551-021-00740-x
摘要
The precise understanding and control of microenvironmental cues could be used to optimize the efficacy of cell therapeutics. Here, we show that mesenchymal stromal cells (MSCs) singly coated with a soft conformal gel presenting defined chemomechanical cues promote matrix remodelling by secreting soluble interstitial collagenases in response to the presence of tumour necrosis factor alpha (TNF-α). In mice with fibrotic lung injury, treatment with the coated MSCs maintained normal collagen levels, fibre density and microelasticity in lung tissue, and the continuous presentation of recombinant TNF-α in the gel facilitated the reversal of aberrant tissue remodelling by the cells when inflammation subsided in the host. Gel coatings with predefined chemomechanical cues could be used to tailor cells with specific mechanisms of action for desired therapeutic outcomes. Mesenchymal stromal cells singly coated with a soft conformal gel incorporating specific chemomechanical cues inhibit aberrant tissue remodelling in mice with fibrotic lung injury.
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