幽门螺杆菌
纳米载体
纳米医学
转化式学习
胃炎
医学
重症监护医学
材料科学
药品
药理学
纳米技术
内科学
心理学
教育学
纳米颗粒
作者
Yuan Qin,Yeh‐Hsing Lao,Haixia Wang,Jiabin Zhang,Ke Yi,Zhuang‐Gui Chen,Jing Han,Wantong Song,Yu Tao,Mingqiang Li
摘要
Helicobacter pylori (H. pylori) infection is considered to be the main cause of most digestive diseases,such as chronic active gastritis, gastroduodenal ulcers, or even gastric cancer. Oral medication is a transformative approach to treat H. pylori-induced infections. However, unlike intravenous administration, orally administrated drugs have to overcome various barriers before reaching the infected sites, which significantly limits the therapeutic efficacy. These challenges may be addressed by emerging nanomedicine that is equipped with nanotechnology approaches to enable efficient and effective targeted delivery of drugs. Herein, in this review, we first discuss the conventional therapy for the eradication of H. pylori. Through the introduction of the critical barriers of oral administration, the benefits of nanomedicine are highlighted. Recently-published examples of nanocarriers for combating H. pylori in terms of design, preparation, and antimicrobial mechanisms are then presented, followed by our perspective on potential future research directions of oral nanomedicines.
科研通智能强力驱动
Strongly Powered by AbleSci AI