疾病
肠道菌群
微生物群
发病机制
肠-脑轴
机制(生物学)
医学
失调
生物信息学
神经科学
生物
肠道微生物群
阿尔茨海默病
厚壁菌
免疫学
内科学
病理
哲学
认识论
作者
Mariana Romanenko,Victor Kholin,Alexander Koliada,Alexander Vaiserman
标识
DOI:10.3389/fpsyt.2021.712673
摘要
Nutrition is known to play an important role in the pathogenesis of Alzheimer's disease. Evidence is obtained that the gut microbiota is a key player in these processes. Dietary changes (both adverse and beneficial) may influence the microbiome composition, thereby affecting the gut-brain axis and the subsequent risk for Alzheimer's disease progression. In this review, the research findings that support the role of intestinal microbiota in connection between nutritional factors and the risk for Alzheimer's disease onset and progression are summarized. The mechanisms potentially involved in these processes as well as the potential of probiotics and prebiotics in therapeutic modulation of contributed pathways are discussed.
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