化学
碎片(计算)
电喷雾电离
串联质谱法
质谱法
质谱
电喷雾
碰撞诱导离解
串联
血管紧张素II
蛋白质质谱法
离子
分析化学(期刊)
色谱法
有机化学
计算机科学
操作系统
材料科学
复合材料
生物化学
受体
标识
DOI:10.1016/j.ijms.2006.02.016
摘要
The characteristic fragmentation pathways of Angiotensin II and eight analogues were investigated by electrospray ionization tandem mass spectrometry. The main fragmentations involve the cleavages of the CCO and CONH bonds with the loss of water, ammonia or carbon monoxide and rearrangements involving hydrogen atoms, and the MS/MS spectra give significant sequence information of these octapeptides. In addition, the two members of the analogues with the same mass and different elemental composition can be distinguished by the MS/MS spectra of [M + H]+ and fragment ions. These results show that ESI tandem mass spectrometry is an excellent tool for the structural identification of Angiotensin II and its analogues.
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