同源盒
生物
基因
遗传学
螺旋(腹足类)
DNA
功能(生物学)
计算生物学
转录因子
进化生物学
生态学
蜗牛
作者
W.J. Gehring,Martin Müller,Markus Affolter,Anthony Percival‐Smith,Martin Billeter,Yan Qiu Qian,Gottfried Otting,Kurt Wüthrich
标识
DOI:10.1016/0168-9525(90)90253-3
摘要
The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.
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