瓦博格效应
细胞代谢
厌氧糖酵解
生物
合成代谢
细胞生物学
线粒体
癌症
信号转导
癌症研究
细胞
癌细胞
生物化学
遗传学
作者
Guido Kroemer,Jacques Pouysségur
出处
期刊:Cancer Cell
[Cell Press]
日期:2008-06-01
卷期号:13 (6): 472-482
被引量:2173
标识
DOI:10.1016/j.ccr.2008.05.005
摘要
The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic metabolism, either as a consequence or as a cause. As an example, the resistance of cancer mitochondria against apoptosis-associated permeabilization and the altered contribution of these organelles to metabolism are closely related. Similarly, the constitutive activation of signaling cascades that stimulate cell growth has a profound impact on anabolic metabolism. Here, we review the peculiarities of tumor cell metabolism that might be taken advantage of for cancer treatment. Specifically, we discuss the alterations in signal transduction pathways and/or enzymatic machineries that account for metabolic reprogramming of transformed cells.
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