Solvent-free and Water Mediated Synthesis of 2-Substituted Imidazolines Using Iron (III) Phosphate

Aldehydes were respectively converted to the corresponding 2-imidazolines in good yields by the reaction with ethylenediamine using iron (III) phosphate on water under reflux condition. Furthermore nitriles were converted to the corresponding 2-imidazolines under solvent-free condition at 100 °C. Utilizing of heterogeneous and recyclable catalyst, water as a solvent and solvent-free condition is the best medium from a green chemistry standpoint. Keywords: Green chemistry, Iron (III) phosphate, Imidazoline, Solvent-free, Water mediated, Reusability of the Catalyst, Iron (III) phosphate, Antihypertensive, Antialzimer, Antitumor