Wnt信号通路
生物
中枢神经系统
细胞生物学
内皮
血管
血脑屏障
神经上皮细胞
器官系统
信号转导
解剖
神经科学
病理
医学
内分泌学
干细胞
神经干细胞
疾病
作者
Jan M. Stenman,Jay Rajagopal,Thomas L. Carroll,Makoto Ishibashi,Jill A. McMahon,Andrew P. McMahon
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2008-11-21
卷期号:322 (5905): 1247-1250
被引量:496
标识
DOI:10.1126/science.1164594
摘要
Every organ depends on blood vessels for oxygen and nutrients, but the vasculature associated with individual organs can be structurally and molecularly diverse. The central nervous system (CNS) vasculature consists of a tightly sealed endothelium that forms the blood-brain barrier, whereas blood vessels of other organs are more porous. Wnt7a and Wnt7b encode two Wnt ligands produced by the neuroepithelium of the developing CNS coincident with vascular invasion. Using genetic mouse models, we found that these ligands directly target the vascular endothelium and that the CNS uses the canonical Wnt signaling pathway to promote formation and CNS-specific differentiation of the organ's vasculature.
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