Colorectal Tumor Microenvironment‐Activated Bio‐Decomposable and Metabolizable Cu2O@CaCO3 Nanocomposites for Synergistic Oncotherapy

nanocomposites can efficiently reprogram the macrophages from the M2 phenotype to the M1 phenotype and initiate a vaccine-like immune effect after primary tumor removal, which further induces an immune-favorable TME and intense immune responses for anti-CD47 antibody to simultaneously inhibit CRC distant metastasis and recurrence by immunotherapy.