Nuclear EGFR: a potential target for radiosensitizer

Nuclear epithelial growth factor receptor (EGFR) plays an important role in the development, metastasis, treatment, and prognosis of cancer. Radiotherapy, one of the main therapies for malignant tumor, causes EGFR transfer into the nucleus along with tumor therapy, thereby reducing radiosensitivity. Insight into the biological characteristics and functions of nuclear EGFR has an important reference value for improving radiosensitivity. Therefore, this article elaborates on EGFR transport into the nucleus, the features of nuclear EGFR, and its relationship with radiosensitivity and clinical targeted therapy. Key words: Epidermal growth factor receptor; Radiosensitivity; Neoplasms/targeted therapy