Effects of thyroid hormone receptor on energy and lipid metabolism

Thyroid hormone (TH) plays a significant role in regulating both energy and lipid metabolism.Since the subtypes of thyroid hormone receptor (TR) have been explored and reported several years ago,numerous studies have been focused on their roles in metabolic regulation.TR can be extensively found in tissues of the human body.The binding of TH and TRβ can lower the levels of cholesterol and triglyceride.Currently,agonist of TRβ has been in clinical trials as a new lipid lowering agent,possibly via reverse cholesterol transport and trans-intestinal cholesterol excretion.The impacts of TR on lipid and energy metabolism are attracting increasingly intense attention.It is prospectively promising to fight clinically against hyperlipidaemia and obesity.It is most likely to grow to be a new target for lipid metabolism disorders and related diseases. Key words: Thyroid hormone ;  Receptor ;  Energy metabolism ;  Obesity ;