活性氧
体内
化学
清除
级联
炎症
计算生物学
生物化学
免疫学
生物
抗氧化剂
色谱法
生物技术
作者
Yufeng Liu,Yuan Cheng,He Zhang,Min Zhou,Yijun Yu,Shichao Lin,Bo Jiang,Xiaozhi Zhao,Leiying Miao,Chuan‐Wan Wei,Quanyi Liu,Ying‐Wu Lin,Yan Du,Christopher J. Butch,Hui Wei
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2020-07-17
卷期号:6 (29)
被引量:271
标识
DOI:10.1126/sciadv.abb2695
摘要
Here, an integrated cascade nanozyme with a formulation of Pt@PCN222-Mn is developed to eliminate excessive reactive oxygen species (ROS). This nanozyme mimics superoxide dismutase by incorporation of a Mn-[5,10,15,20-tetrakis(4-carboxyphenyl)porphyrinato]-based metal-organic framework compound capable of transforming oxygen radicals to hydrogen peroxide. The second mimicked functionality is that of catalase by incorporation of Pt nanoparticles, which catalyze hydrogen peroxide disproportionation to water and oxygen. Both in vitro and in vivo experimental measurements reveal the synergistic ROS-scavenging capacity of such an integrated cascade nanozyme. Two forms of inflammatory bowel disease (IBD; i.e., ulcerative colitis and Crohn's disease) can be effectively relieved by treatment with the cascade nanozyme. This study not only provides a new method for constructing enzyme-like cascade systems but also illustrates their efficient therapeutic promise in the treatment of in vivo IBDs.
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