化学
废止
分子内力
三环
催化作用
级联
分子
立体化学
级联反应
组合化学
有机化学
色谱法
作者
Hongmei Xie,Ming Zhong,Hua‐Jie Kang,Bing Shu,Shang‐Shi Zhang
标识
DOI:10.1002/adsc.202001380
摘要
Abstract A highly efficient cascade Rh(III)‐catalyzed C−H activation/intramolecular chemodivergent cyclization reaction of N‐carbamoylindoles and sulfoxonium ylides has been successfully achieved for the first time. This synergistic process provides rapid access to functionalized dihydropyrimidoindolone and tricyclic [1,3]oxazino[3,4‐ a ]indol‐1‐ones skeletons under redox neutral conditions with broad substrate scope and remarkable functional‐group compatibility. Further late‐stage modification of structurally complex drug molecules and mechanistic studies were also accomplished. magnified image
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