Natural compounds against doxorubicin‐induced cardiotoxicity: A review on the involvement of Nrf2/ARE signaling pathway

Cardiotoxicity is the main concern for long‐term use of the doxorubicin (DOX). Reactive oxygen species (ROS) generation leads to oxidative stress that significantly contributes to the cardiac damage induced by DOX. The nuclear factor erythroid 2‐related factor (Nrf2) acts as a protective player against DOX‐induced myocardial oxidative stress. Several natural compounds (NCs) with anti‐oxidative effects, were examined to suppress DOX cardiotoxicity such as asiatic acid, α‐linolenic acid, apigenin, baicalein, β‐lapachone, curdione, dioscin, ferulic acid, Ganoderma lucidum polysaccharides, genistein, ginsenoside Rg3, indole‐3‐carbinol, naringenin‐7‐ O ‐glucoside, neferine, p‐coumaric acid, pristimerin, punicalagin, quercetin, sulforaphane, and tanshinone IIA. The present article, reviews NCs that showed protective effects against DOX‐induced cardiac injury through induction of Nrf2 signaling pathway.