DNA甲基化
生物
表观遗传学
遗传学
甲基化
表观遗传学
RNA导向的DNA甲基化
DNA
遗传(遗传算法)
有丝分裂
计算生物学
基因
基因表达
作者
Xuan Ma,Bing Zhu,Yingfeng Li
标识
DOI:10.1016/j.jgg.2021.01.006
摘要
Decades of investigation on DNA methylation have led to deeper insights into its metabolic mechanisms and biological functions. This understanding was fueled by the recent development of genome editing tools and our improved capacity for analyzing the global DNA methylome in mammalian cells. This review focuses on the maintenance of DNA methylation patterns during mitotic cell division. We discuss the latest discoveries of the mechanisms for the inheritance of DNA methylation as a stable epigenetic memory. We also highlight recent evidence showing the rapid turnover of DNA methylation as a dynamic gene regulatory mechanism. A body of work has shown that altered DNA methylomes are common features in aging and disease. We discuss the potential links between methylation maintenance mechanisms and disease-associated methylation changes.
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