静电纺丝
聚己内酯
壳聚糖
生物相容性
纳米纤维
热稳定性
材料科学
化学工程
粘附
扫描电子显微镜
伤口愈合
抗菌活性
核化学
化学
纳米技术
复合材料
聚合物
有机化学
冶金
免疫学
细菌
工程类
生物
遗传学
作者
Parinaz Nezhad‐Mokhtari,Fahimeh Kazeminava,Bahman Abdollahi,Pourya Gholizadeh,Abolfazl Heydari,Faranak Elmi,Mahmoud Abbaszadeh,Hossein Samadi Kafil
标识
DOI:10.1016/j.ijbiomac.2023.125718
摘要
Recently, developing antibacterial wound dressings based on biomaterials display good biocompatibility and the potential to accelerate wound healing. For this aim, we prepared eco-friendly and biodegradable nanofibers (NFs) based on N-(3-sulfopropyl)chitosan/ poly (ε-caprolactone) incorporated by zeolite imidazolate framework-8 nanoparticles (ZIF-8 NPs) and chamomile essential oil (MCEO) via the electrospinning technique for their efficacy as wound dressing scaffolds. Fabricated NFs were characterized and studied for their structural, morphological, mechanical, hydrophilic, and thermal stability properties. The results of scanning electron microscopy (SEM) revealed that adding the ZIF-8 NPs/ MCEO, very slightly influenced the average diameter of NFs (PCL/SPCS (90:10) with 90 ± 32 nm). The developed uniform MCEO-loaded ZIF-8/PCL/SPCS NFs displayed better cytocompatibility, proliferation, and physicochemical properties (e.g. thermal stability and mechanical properties) than neat NFs. The results of cytocompatibility, DAPI (4′,6-diamidino-2-phenylindole) staining study, and SEM micrographs demonstrated that formulated NFs had promising adhesion and proliferation against normal human foreskin fibroblasts-2 (HFF-2 cell line). The prepared NFs revealed excellent antibacterial activity against both Staphylococcus aureus and Escherichia coli with inhibition of 32.3 mm and 31.2 mm, respectively. Accordingly, the newly developed antibacterial NFs hold great potential as effective biomaterials for use as an active platform in wound healing applications.
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