HDAC8型
癌症研究
髓系白血病
白血病
组蛋白脱乙酰基酶
髓样
化学
组蛋白
医学
免疫学
基因
生物化学
作者
Sk. Abdul Amin,Samima Khatun,Shovanlal Gayen,Sanjib Das,Tarun Jha
标识
DOI:10.1016/j.ejmech.2023.115594
摘要
Histone deacetylase 8 (HDAC8) aberrantly deacetylates histone and non-histone proteins. These include structural maintenance of chromosome 3 (SMC3) cohesin protein, retinoic acid induced 1 (RAI1), p53, etc and thus, regulating diverse processes such as leukemic stem cell (LSC) transformation and maintenance. HDAC8, one of the crucial HDACs, affects the gene silencing process in solid and hematological cancer progressions especially on acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). A specific HDAC8 inhibitor PCI-34051 showed promising results against both T-cell lymphoma and AML. Here, we summarize the role of HDAC8 in hematological malignancies, especially in AML and ALL. This article also introduces the structure/function of HDAC8 and a special attention has been paid to address the HDAC8 enzyme selectivity issue in hematological cancer especially against AML and ALL.
科研通智能强力驱动
Strongly Powered by AbleSci AI