病毒学
助推器(火箭)
免疫系统
生物
免疫
2019年冠状病毒病(COVID-19)
免疫学
医学
疾病
传染病(医学专业)
物理
病理
天文
作者
Iana H. Haralambieva,Jonathon M Monroe,Inna G. Ovsyannikova,Nathaniel D. Warner,Diane E. Grill,Gregory A. Poland,Richard B. Kennedy
出处
期刊:Vaccine
[Elsevier]
日期:2024-01-01
标识
DOI:10.1016/j.vaccine.2024.01.032
摘要
The responsiveness/cross-binding of vaccine-induced memory B cells/MBCs to previous and emerging divergent SARS-CoV-2 variants (e.g., Omicron) is understudied. In this longitudinal study subjects receiving two or three doses of monovalent ancestral strain-containing COVID-19 mRNA vaccine were evaluated. In contrast to others, we observed significantly lower frequencies of MBCs reactive to the receptor-binding domain/RBD, the N-terminal domain/NTD, and the S1 of Omicron/BA.1, compared to Wuhan and Delta, even after a 3rd vaccine dose/booster. Our study is a proof of concept that MBC cross-reactivity to variants with greater sequence divergence from the vaccine strain may be overestimated and suggests that these variants may exhibit immune escape with reduced recognition by circulating pre-existing MBCs upon infection.
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