Awakening neural survival mechanisms after stroke: Lipid metabolism in brain-autonomous repair

In this issue of Neuron, Nakamura et al. 1 Nakamura A. Sakai S. Taketomi Y. Tsuyama J. Miki Y. Hara Y. Arai N. Sugiura Y. Kawaji H. Murakami M. Shichita T. PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke. Neuron. 2023; S0896-6273 (00483-X)https://doi.org/10.1016/j.neuron.2023.06.024 Abstract Full Text Full Text PDF Scopus (2) Google Scholar report the discovery that neuronally secreted phospholipase PLA2G2E releases dihomo-γ-linolenic acid (DGLA) that generates 15-hydroxy-eicosatrienoic acid (15-HETrE), which in turn induces peptidyl arginine deiminase 4 (PAD4/PADI4) to elicit neuronal pro-survival and pro-reparative events following ischemic brain injury. In this issue of Neuron, Nakamura et al. 1 Nakamura A. Sakai S. Taketomi Y. Tsuyama J. Miki Y. Hara Y. Arai N. Sugiura Y. Kawaji H. Murakami M. Shichita T. PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke. Neuron. 2023; S0896-6273 (00483-X)https://doi.org/10.1016/j.neuron.2023.06.024 Abstract Full Text Full Text PDF Scopus (2) Google Scholar report the discovery that neuronally secreted phospholipase PLA2G2E releases dihomo-γ-linolenic acid (DGLA) that generates 15-hydroxy-eicosatrienoic acid (15-HETrE), which in turn induces peptidyl arginine deiminase 4 (PAD4/PADI4) to elicit neuronal pro-survival and pro-reparative events following ischemic brain injury. PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic strokeNakamura et al.NeuronJuly 24, 2023In BriefPLA2G2E from peri-infarct-surviving neurons metabolizes phosphatidylserine to DGLA and 15-HETrE, which triggers functional recovery after ischemic stroke. These reparative lipid mediators induce PADI4 in peri-infarct-surviving neurons to initiate neural repair-associated gene expression through histone citrullination, demonstrating brain-autonomous extensive repair capabilities through lipid metabolism. Full-Text PDF