串扰
免疫系统
细胞外小泡
细胞生物学
炎症
细胞
发病机制
肾缺血
细胞外
胞外囊泡
微泡
小泡
生物
医学
缺血
再灌注损伤
免疫学
膜
生物化学
内科学
小RNA
物理
基因
光学
作者
Xiaodong Zhao,Yunkuo Li,Shouwang Wu,Yu-Xiong Wang,Bin Liu,Honglan Zhou,Faping Li
标识
DOI:10.1016/j.biopha.2023.115229
摘要
Renal ischemia-reperfusion injury (RIRI) is a complex disorder characterized by both intrinsic damage to renal tubular epithelial cells and extrinsic inflammation mediated by cytokines and immune cells. Unfortunately, there is no cure for this devastating condition. Extracellular vesicles (EVs) are nanosized membrane-bound vesicles secreted by various cell types that can transfer bioactive molecules to target cells and modulate their function. EVs have emerged as promising candidates for cell-free therapy of RIRI, owing to their ability to cross biological barriers and deliver protective signals to injured renal cells. In this review, we provide an overview of EVs, focusing on their functional role in RIRI and the signaling messengers responsible for EV-mediated crosstalk between various cell types in renal tissue. We also discuss the renoprotective role of EVs and their use as therapeutic agents for RIRI, highlighting the advantages and challenges encountered in the therapeutic application of EVs in renal disease.
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