摘要
HomeCirculation: Cardiovascular ImagingVol. 16, No. 11Remnant Cholesterol—A Novel Risk Marker for Left Ventricular Remodeling and Dysfunction No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextRemnant Cholesterol—A Novel Risk Marker for Left Ventricular Remodeling and Dysfunction Benjamin Nilsson Wadström and Hashmat Sayed Zohori Bahrami Benjamin Nilsson WadströmBenjamin Nilsson Wadström Correspondence to: Benjamin Nilsson Wadström, MD Department of Clinical Biochemistry, Herlev og Gentofte Hospital, Copenhagen University Hospital, Borgmester Ib Juuls Vej 73, entrance 7, 4th Floor, N5, 2730 Herlev, Denmark. Email E-mail Address: [email protected] https://orcid.org/0000-0003-1913-7472 Department of Clinical Biochemistry (B.N.W.), Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark. The Copenhagen General Population Study (B.N.W.), Herlev and Gentofte Hospital, Copenhagen University Hospital, Denmark. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (B.N.W., H.S.Z.B.). Search for more papers by this author and Hashmat Sayed Zohori BahramiHashmat Sayed Zohori Bahrami Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark (B.N.W., H.S.Z.B.). Department of Cardiology, Amager and Hvidovre Hospital, Copenhagen University Hospital, Denmark (H.S.Z.B.). Department of Clinical Research, Steno Diabetes Center Copenhagen, Denmark (H.S.Z.B.). Search for more papers by this author Originally published21 Nov 2023https://doi.org/10.1161/CIRCIMAGING.123.016110Circulation: Cardiovascular Imaging. 2023;16This article is a commentary on the followingRemnant Cholesterol in Young Adulthood Is Associated With Left Ventricular Remodeling and Dysfunction in Middle Age: The CARDIA StudyFootnotesFor Disclosures, see page 903.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Correspondence to: Benjamin Nilsson Wadström, MD Department of Clinical Biochemistry, Herlev og Gentofte Hospital, Copenhagen University Hospital, Borgmester Ib Juuls Vej 73, entrance 7, 4th Floor, N5, 2730 Herlev, Denmark. Email karl.benjamin.walter.nilsson.wadstroem@regionh.dkREFERENCES1. Xu X, Huang R, Guo Y, Xiong Z, Zhuang X, Liao X. Remnant cholesterol in young adulthood is associated with left ventricular remodeling and dysfunction in middle age: the CARDIA study.Circ Cardiovasc Imaging. 2023; 16:e015589. doi: 10.1161/CIRCIMAGING.123.015589LinkGoogle Scholar2. Doi T, Langsted A, Nordestgaard BG. Elevated remnant cholesterol reclassifies risk of ischemic heart disease and myocardial infarction.J Am Coll Cardiol. 2022; 79:2383–2397. doi: 10.1016/j.jacc.2022.03.384CrossrefMedlineGoogle Scholar3. Nordestgaard BG. Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology.Circ Res. 2016; 118:547–563. doi: 10.1161/CIRCRESAHA.115.306249LinkGoogle Scholar4. Chait A, Ginsberg HN, Vaisar T, Heinecke JW, Goldberg IJ, Bornfeldt KE. Remnants of the triglyceride-rich lipoproteins, diabetes, and cardiovascular disease.Diabetes. 2020; 69:508–516. doi: 10.2337/dbi19-0007CrossrefMedlineGoogle Scholar5. Chan J, Hanekom L, Wong C, Leano R, Cho GY, Marwick TH. Differentiation of subendocardial and transmural infarction using two-dimensional strain rate imaging to assess short-axis and long-axis myocardial function.J Am Coll Cardiol. 2006; 48:2026–2033. doi: 10.1016/j.jacc.2006.07.050CrossrefMedlineGoogle Scholar6. Liu J, Fan F, Liu B, Li K, Jiang Y, Jia J, Chen C, Zheng B, Zhang Y. Association between remnant cholesterol and arterial stiffness in a Chinese community-based population: a cross-sectional study.Front Cardiovasc Med. 2022; 9:993097. doi: 10.3389/fcvm.2022.993097CrossrefMedlineGoogle Scholar7. Xu M, Huang Y, Xie L, Peng K, Ding L, Lin L, Wang P, Hao M, Chen Y, Sun Y, et al. Diabetes and risk of arterial stiffness: a mendelian randomization analysis.Diabetes. 2016; 65:1731–1740. doi: 10.2337/db15-1533CrossrefMedlineGoogle Scholar8. Ye C, Kong L, Zhao Z, Li M, Wang S, Lin H, Xu Y, Lu J, Chen Y, Xu Y, et al. Causal associations of obesity with chronic kidney disease and arterial stiffness: a mendelian randomization study.J Clin Endocrinol Metab. 2022; 107:e825–e835. doi: 10.1210/clinem/dgab633CrossrefMedlineGoogle Scholar9. van Heerebeek L, Hamdani N, Handoko ML, Falcao-Pires I, Musters RJ, Kupreishvili K, Ijsselmuiden AJ, Schalkwijk CG, Bronzwaer JG, Diamant M, et al. Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension.Circulation. 2008; 117:43–51. doi: 10.1161/CIRCULATIONAHA.107.728550LinkGoogle Scholar10. Chirinos JA, Segers P, Hughes T, Townsend R. Large-artery stiffness in health and disease: JACC state-of-the-art review.J Am Coll Cardiol. 2019; 74:1237–1263. doi: 10.1016/j.jacc.2019.07.012CrossrefMedlineGoogle Scholar11. Zamani P, Bluemke DA, Jacobs DR, Duprez DA, Kronmal R, Lilly SM, Ferrari VA, Townsend RR, Lima JA, Budoff M, et al. Resistive and pulsatile arterial load as predictors of left ventricular mass and geometry: the multi-ethnic study of atherosclerosis.Hypertension. 2015; 65:85–92. doi: 10.1161/HYPERTENSIONAHA.114.04333LinkGoogle Scholar12. Chirinos JA, Segers P, Rietzschel ER, De Buyzere ML, Raja MW, Claessens T, De Bacquer D, St John Sutton M, Gillebert TC, Asklepios I. Early and late systolic wall stress differentially relate to myocardial contraction and relaxation in middle-aged adults: the Asklepios study.Hypertension. 2013; 61:296–303. doi: 10.1161/HYPERTENSIONAHA.111.00530LinkGoogle Scholar13. Linhart A, Cecchi F. Common presentation of rare diseases: Left ventricular hypertrophy and diastolic dysfunction.Int J Cardiol. 2018; 257:344–350. doi: 10.1016/j.ijcard.2018.01.006CrossrefMedlineGoogle Scholar14. Westermann D, Kasner M, Steendijk P, Spillmann F, Riad A, Weitmann K, Hoffmann W, Poller W, Pauschinger M, Schultheiss HP, et al. Role of left ventricular stiffness in heart failure with normal ejection fraction.Circulation. 2008; 117:2051–2060. doi: 10.1161/CIRCULATIONAHA.107.716886LinkGoogle Scholar15. Mordi IR, Lumbers RT, Palmer CNA, Pearson ER, Sattar N, Holmes MV, Lang CC, Consortium H. Type 2 diabetes, metabolic traits, and risk of heart failure: a mendelian randomization study.Diabetes Care. 2021; 44:1699–1705. doi: 10.2337/dc20-2518CrossrefMedlineGoogle Scholar16. Ridker PM, Rane M. Interleukin-6 signaling and anti-interleukin-6 therapeutics in cardiovascular disease.Circ Res. 2021; 128:1728–1746. doi: 10.1161/CIRCRESAHA.121.319077LinkGoogle Scholar17. Varbo A, Benn M, Tybjaerg-Hansen A, Nordestgaard BG. Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation.Circulation. 2013; 128:1298–1309. doi: 10.1161/CIRCULATIONAHA.113.003008LinkGoogle Scholar18. Guan B, Wang A, Xu H. Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis.Cardiovasc Diabetol. 2023; 22:207. doi: 10.1186/s12933-023-01927-zCrossrefMedlineGoogle Scholar19. Wadstrom BN, Wulff AB, Pedersen KM, Jensen GB, Nordestgaard BG. Elevated remnant cholesterol increases the risk of peripheral artery disease, myocardial infarction, and ischaemic stroke: a cohort-based study.Eur Heart J. 2022; 43:3258–3269. doi: 10.1093/eurheartj/ehab705CrossrefMedlineGoogle Scholar20. Wadstrom BN, Pedersen KM, Wulff AB, Nordestgaard BG. Elevated remnant cholesterol, plasma triglycerides, and cardiovascular and non-cardiovascular mortality.Eur Heart J. 2023; 44:1432. doi: 10.1093/eurheartj/ehac822CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesRemnant Cholesterol in Young Adulthood Is Associated With Left Ventricular Remodeling and Dysfunction in Middle Age: The CARDIA StudyXinghao Xu, et al. Circulation: Cardiovascular Imaging. 2023;16 November 2023Vol 16, Issue 11 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCIMAGING.123.016110PMID: 37988445 Originally publishedNovember 21, 2023 KeywordsEditorialsheart failureinflammationobesitytriglyceride-rich lipoproteinsPDF download Advertisement SubjectsLipids and CholesterolMetabolic SyndromePrimary PreventionRemodelingRisk Factors