楔前
心理学
默认模式网络
流行病学研究中心抑郁量表
萧条(经济学)
认知
听力学
贝克抑郁量表
神经心理学
精神科
临床心理学
抑郁症状
医学
焦虑
宏观经济学
经济
作者
Gábor Csukly,László Tombor,Zoltán Hidasi,Éva Csibri,Máté Fullajtár,Zsolt Huszár,Vanda Koszovácz,Orsolya Lányi,Edit Vass,Boróka Koleszár,István Kóbor,Katalin Farkas,Víctor Rosenfeld,Dalida Borbála Berente,G. Bolla,Máté G. Kiss,Anita Kamondi,András Horváth
标识
DOI:10.1038/s41398-024-02891-2
摘要
Abstract Evidence suggests that depressive symptomatology is a consequence of network dysfunction rather than lesion pathology. We studied whole-brain functional connectivity using a Minimum Spanning Tree as a graph-theoretical approach. Furthermore, we examined functional connectivity in the Default Mode Network, the Frontolimbic Network (FLN), the Salience Network, and the Cognitive Control Network. All 183 elderly subjects underwent a comprehensive neuropsychological evaluation and a 3 Tesla brain MRI scan. To assess the potential presence of depressive symptoms, the 13-item version of the Beck Depression Inventory (BDI) or the Geriatric Depression Scale (GDS) was utilized. Participants were assigned into three groups based on their cognitive status: amnestic mild cognitive impairment (MCI), non-amnestic MCI, and healthy controls. Regarding affective symptoms, subjects were categorized into depressed and non-depressed groups. An increased mean eccentricity and network diameter were found in patients with depressive symptoms relative to non-depressed ones, and both measures showed correlations with depressive symptom severity. In patients with depressive symptoms, a functional hypoconnectivity was detected between the Anterior Cingulate Cortex (ACC) and the right amygdala in the FLN, which impairment correlated with depressive symptom severity. While no structural difference was found in subjects with depressive symptoms, the volume of the hippocampus and the thickness of the precuneus and the entorhinal cortex were decreased in subjects with MCI, especially in amnestic MCI. The increase in eccentricity and diameter indicates a more path-like functional network configuration that may lead to an impaired functional integration in depression, a possible cause of depressive symptomatology in the elderly.
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