纳米凝胶
伤口愈合
血管生成
氧化还原
活性氧
炎症
体内
化学
细胞生物学
壳聚糖
癌症研究
生物化学
免疫学
生物
药物输送
有机化学
生物技术
作者
Mousumi Das,Susmita Mondal,Ria Ghosh,Soumendra Darbar,Lopamudra Roy,Anjan Kumar Das,Debasish Pal,Siddhartha Bhattacharya,Asim Kumar Mallick,Jayanta Kundu,Samir Kumar Pal
摘要
In the study, we have shown the efficacy of an indigenously developed redox balancing chitosan gel with impregnated citrate capped Mn3O4 nanoparticles (nanogel). Application of the nanogel on a wound of preclinical mice model shows role of various signaling molecules and growth factors, and involvement of reactive oxygen species (ROS) at every stage, namely hemostasis, inflammation, and proliferation leading to complete maturation for the scarless wound healing. While in vitro characterization of nanogel using SEM, EDAX, and optical spectroscopy reveals pH regulated redox buffering capacity, in vivo preclinical studies on Swiss albino involving IL-12, IFN-γ, and α-SMA signaling molecules and detailed histopathological investigation and angiogenesis on every stage elucidate role of redox buffering for the complete wound healing process.
科研通智能强力驱动
Strongly Powered by AbleSci AI