医学
更安全的
肺癌
尼古丁
慢性阻塞性肺病
电子烟
肺
DNA损伤
哮喘
免疫学
环境卫生
重症监护医学
生物
内科学
病理
计算机安全
计算机科学
DNA
遗传学
作者
Kassandra Allbright,J. Villandre,Laura E. Crotty Alexander,Michael S. Zhang,Kambez H. Benam,John Evankovich,Mélanie Königshoff,Divay Chandra
出处
期刊:The European respiratory journal
[European Respiratory Society]
日期:2024-04-12
卷期号:: 2301494-2301494
标识
DOI:10.1183/13993003.01494-2023
摘要
Electronic cigarette (e-cigarette) use continues to rise globally. E-cigarettes have been presented as safer alternatives to combustion cigarettes that can mitigate the harm associated with tobacco products; however, the degree to which e-cigarette use itself can lead to morbidity and mortality is not fully defined. Herein we describe how e-cigarettes function; discuss the current knowledge of the effects of e-cigarette aerosol on lung cell cytotoxicity, inflammation, anti-pathogen immune response, mucociliary clearance, oxidative stress, DNA damage, carcinogenesis, matrix remodeling, and airway hyperresponsiveness; and summarize the impact on lung diseases, including COPD, respiratory infection, lung cancer, and asthma. We highlight how the inclusion of nicotine or flavoring compounds in e-liquids can impact lung toxicity. Finally, we consider the paradox of the safer cigarette - the toxicities of e-cigarettes that can mitigate their potential to serve as a harm reduction tool in the fight against traditional cigarettes, and we summarize the research needed in this under-investigated area.
科研通智能强力驱动
Strongly Powered by AbleSci AI