胰岛素抵抗
脂肪变性
谷氨酰胺
肠道菌群
炎症
脂多糖
胰岛素
免疫学
内分泌学
内科学
生物
医学
生物化学
氨基酸
作者
Zhongting Lu,Yan Zheng,Juan Zheng,Qijian Liang,Qingcai Zhen,Mengjie Cui,Haoru Yang,Haiwei Wu,Chengming Tian,Kangming Zhu,Chunyong Bian,Lingbin Du,Hao Wu,Xin Guo
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2024-01-01
摘要
Fu Brick tea belongs to fermented dark tea, which is one of the six categories of tea. Fu Brick tea has been reported to reduce adiposity and has beneficial effects in the treatment of hypercholesterolemia and cardiovascular disease. Theabrownin (TB) is one of the pigments with the most abundant content in Fu Brick tea. TB has also been reported to have lipid-lowering effects, but its mechanism remains unclear. We found that TB could effectively reduce the insulin resistance and fat deposition induced by a high fat diet (HFD), decrease inflammation in the liver, improve intestinal integrity, and reduce endotoxins in circulation. Further studies showed that TB increased the abundance of Verrucomicrobiota and reduced the abundance of Firmicutes and Desulfobacterota in the intestinal tract of obese mice. The alteration of gut microbiota is closely linked to the metabolic phenotype after TB treatment through correlation analysis. Moreover, TB changed the gut microbial metabolites including L-ornithine, α-ketoglutarate, and glutamine, which have also been found to be upregulated in the liver after TB intervention. In vitro, L-ornithine, α-ketoglutarate, or glutamine significantly reduced lipopolysaccharide (LPS)-induced inflammation in macrophages. Therefore, our results suggest that TB can reduce adiposity, systemic insulin resistance, and liver inflammation induced by a HFD through altering gut microbiota and improving the intestinal tight junction integrity. The metabolites of gut microbiota might also play a role in ameliorating the HFD-induced phenotype by TB.
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